A cross-town delivery and a Los Angeles to Sacramento run are not the same operation performed at different scales. Extended transit time changes what a passive thermal package has to hold for. It changes how much of the day a single driver can cover. It changes how far a shipment is from its origin when something goes wrong, and how long recovery takes if the recipient turns out to be unavailable on arrival.
Long routes also change the arithmetic of a failed handoff. A local redelivery costs an hour. A failed handoff three hundred miles out means the medication is a long way from the pharmacy that released it, often late in the day, frequently with a treatment date attached to it. That is the scenario long-distance planning exists to prevent.
MedMove plans these routes as complete missions rather than as delivery stops. Pickup timing, drive time, thermal duration, recipient availability at the far end, and the contingency if that recipient is not there are all settled before the vehicle moves.